Search on: KETOL ACID REDUCTOISOMERASE 
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Descriptor English:   Ketol-Acid Reductoisomerase 
Descriptor Spanish:   Cetoácido Reductoisomerasa 
Descriptor Portuguese:   Cetol-Ácido Redutoisomerase 
Synonyms English:   Acetohydroxy Acid Isomeroreductase
Acid Isomeroreductase, Acetohydroxy
Alpha Acetohydroxyacid Isomeroreductase
Alpha-Acetohydroxyacid Isomeroreductase
Dihydroxyisovalerate Dehydrogenase (Isomerizing)
Hydroxyacid Reductoisomerase
Isomeroreductase
Isomeroreductase, Acetohydroxy Acid
Isomeroreductase, Alpha-Acetohydroxyacid
Ketol Acid Reductoisomerase
Reductoisomerase, Hydroxyacid
Reductoisomerase, Ketol-Acid  
Tree Number:   D08.811.682.047.820.487
Definition English:   An enzyme that catalyzes the oxidation of (R)-2,3-dihydroxy-3-methylbutanoate to (S)-2-hydroxy-2-methyl-3-oxobutanoate in the presence of NADP. It is involved in the biosynthesis of VALINE; LEUCINE; ISOLEUCINE; pentothenate and COENZYME A. This enzyme was formerly classified as EC 1.1.1.89. 
History Note English:   2006(1980); use VALERATES 1970-1979 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   50599 
Unique Identifier:   D050540 

Occurrence in VHL:
 

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